The role of the immune system
The immune system is a complex system that can be compared to a defending army: always ready to protect the body against attackers such as viruses, bacteria, fungi and other foreign invaders that may cause harm.
The troops
The immune system can be divided into two distinct parts: the first line of defence is the so-called innate immune system. Examples include the skin, which essentially acts as a protective shell against invaders, and the stomach acid by killing off most bacteria from food.the immune system
simply overreacts
to a stimulus
Antibodies
Different types of white blood cells perform the main tasks of the immune system. While some of these cells simply kill the invader, others produce so-called antibodies ("Immunoglobulins") specific to that particular invader profile. These antibodies bind to the invader, thereby deactivating it and making it an easier target for killer cells.Memory cells
Certain cells of the immune system become memory cells after they've been exposed to an invader: They will remember this specific invader and will be able to launch a more powerful and quicker immune response when they have any future contact with it. This is the precise mechanism that makes vaccination effective. Your dog's immune system develops memory cells for the particular virus that is administered with the vaccination. If the dog then comes into contact with this virus in a real life situation, the immune system is already prepared and can react swiftly.In a food allergy, memory cells have been formed for harmless proteins found in food.
What happens in an allergy
For reasons that are not fully understood, the immune system doesn't always function properly. In a dog with a food allergy, the immune system mistakes food, most often protein, for an invader and mounts an attack. It is therefore the immune response that causes the symptoms, and not the substance itself ("allergen").In a food allergy, the immune system simply overreacts to a stimulus. Immune cells are wrongly alerted to harmless proteins and perform their actions, and antibodies are produced to target those proteins that are not foreign attackers.

With ongoing exposure to the allergen, the inflammation can become chronic and manifest itself in other parts of the body than the digestive tract, such as in symptoms affecting the skin or recurrent ear infections.
Prebiotics
The hypersensitive immune system of a dog with an allergy to one or more food proteins can recover over time if these protein sources are excluded from the diet. The period of the exclusion diet can also give the dog's digestive system the chance to regain health.The mucous membrane of the gut is part of the innate immune system and populated by billions of "good" bacteria. When the intestinal flora becomes imbalanced, as can happen in food allergies, the dog may become more susceptible to illness. For instance the dog may suffer from diarrhoea which then affects the absorption of key nutrients. So-called prebiotics which are certain types of fibre stimulate the proliferation of the "good" bacteria and help the dog regain digestive health.
Read more about exclusion diet.
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